Forskolin 50
PrimaForce - Coleus Forskholli 60 Capsules

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Forskolin
This "power" herb has an active ingredient in it called forskolin. It has been used in ayruvedic medicine for many years. Forskolin's basic mechanism of action is that it increases the amount of cyclic AMP (adenosine monophosphate) in cells by activating an enzyme called adenylate cyclase.

Cyclic AMP (cAMP) is one of the most important secondary messengers in the cell. It is considered to be one of the most important cell regulating compounds.

Under normal circumstances, cAMP forms by adenylate cyclase activation due to hormonal stimulation at the cell receptor site. However, forskolin seems to bypass this reaction and allows for an increase in intracellular cAMP to occur. Why is it important to increase cAMP levels? Well, there are several benefits of this to athletes including relaxation of the arteries and smooth muscles, lowering blood pressure, enhanced insulin secretion (which can help drive carbohydrates and protein into muscle cells for energy and recovery), increased thyroid hormone function (which can help enhance metabolic rate), and significantly increase lipolysis (fat burning). Forskolin also seems to benefit other cellular enzymes as well.

The breakdown of fat for fuel (lipolysis) is actually regulated by cAMP. Forskolin has been shown to not only enhance lipolysis but it may also inhibit fat storage from occurring. This is very good news for individuals trying to lose bodyfat and get lean. Another way that forskolin may allow for fat loss to occur is by stimulating thyroid hormone production and release. Thyroid hormone controls metabolism and can enhance metabolic rate, which may translate into more fat loss.

One of the overlooked benefits of forskolin includes its stimulation of digestive enzymes, which can allow individuals to digest and assimilate their food better. It has been shown to increase nutrient absorption in the small intestine.

Asthma and Allergies
Asthma and other allergic conditions are characterized by decreased cAMP levels in bronchial smooth muscle, as well as high levels of PAE In response to allergenic stimuli, mast cells degranulate, histamine is released, and bronchial smooth muscle contracts. Forskolin's activation of cAMP inhibits human basophil and mast cell degranulation, resulting in subsequent bronchodilation.

Dose
1fast400 Coleus forskohlii extracts are standardized to 20-percent forskolin, with recommended dosages ranging from 20-50 mg twice daily. Forskolin has been shown to be safe and effective and has a great amount of potential as a sports supplement.


Forskolin
is a labdane diterpene that is produced by the Indian Coleus plant (Coleus forskohlii). Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cyclic Adenosine Monophosphate (cyclic AMP or cAMP). Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones. It acts by activating protein kinase A.

  • Applied with rolipram, forskolin provides a route to inhibition of colon cancer cell growth and survival. [1]
  • Forskolin is a vasodilator.
  • To date, there have been more than two clinical studies examining the effectiveness of forskolin as a weight loss aid. Only one has been subject to peer-review and published in a medical journal. This clinical study also observed forskolin's role in significantly increasing lean mass, bone mass, and testosterone in the subjects involved.[2] This research has led to companies marketing forskolin as a Bodybuilding supplement.
  • Forskolin may be helpful to control the underlying cause of glaucoma. The sometimes successful use of forskolin to reduce intraocular pressure may be due to its unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP) which regulates and activates critical enzymes required for the cellular energy required to move fluid out of the eye.
  • Increase skin's natural resistance to burning under UV light (see links below)
  • Stimulate a tanning response when applied topically.
  • Reduce urinary tract infections and enhance the ability of antibiotics to kill bacteria that normally survive.

Forskolin can also be used to promote nerve repair by increasing cAMP concetrations. Forskolin can activate or upregulate the proliferation of Schwann cells in culture, together with Fibroblast growth factor or Transforming Growth Factor-Beta.

Various experimental studies are underway in using Forskolin as an adjunct treatment for diseases such as Parkinsons and/or nerve damage caused by trauma/accident.

Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 60
  Amount Per Serving % DV
Coleus forskholii extract (root) (standarized to 20% yielding 50 mg active forskolin) 250mg  
** Daily Value (DV) not established.

Other Ingredients:
Hydroxyproply Methylcellulose & Magnesium Stearate.

Directions:
As a dietary supplement, consume 1-2 capsules per day on an empty stomach.

Warnings:
Not for use by individuals under the age of 18 years of age. Consult a physician prior to use if you have any medical condition including but not limited to: strokes, high blood pressure, heart, liver, kidney or thyroid disease, diabetes, anemia, depression, anxiety, other psychiatric conditions, a family history of these or any other medical conditions, or if using any prescription, OTC, and/or other herbal medications.

These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure or prevent any disease.